Tom Measurement

Kuhner AG

Kuhner TOM (Transfer-Rate Online Measurement) measures online oxygen transfer rate (OTR), carbon dioxide transfer rate (CTR) and the respiratory quotient (RQ) in up to 16 individual shake flasks for better process understanding and informed process development. TOM is easily installed in any Kuhner shaker and can be operated with various flask types and sizes including single use shake flasks. 

The Kuhner TOM captures the progress of multiple cultivations over time, providing an opportunity for the user to selectively schedule off-line sampling and analysis at critical time points. The TOM offers valuable insight on the viability and growth rate of shaken cultivations and will also help identify sub-optimal conditions, including oxygen limitation, substrate limitation, or product inhibition. The TOM also provides an opportunity for the systematic and rapid optimization of culture media and conditions (e.g. balancing different carbon sources or media additives, substrate uptake and product formation via RQ). The OTR, CTR, and RQ data captured from the TOM will accelerate any process development and facilitate scale-up.     

Benefits: 

  • Measures online OTR, CTR and RQ for up to 16 shake flasks  
  • Modular design: choose between 4, 8, 12 or 16 shake flasks 
  • Zero footprint on the shaker tray, TOM is mounted above the shake flasks 
  • Robust: durable sensors and static electronics 
  • Available for Kuhner ISF1-Z, LT-X and Kuhner Kelvin+ incubators 
  • Various glass and single use flasks can be connected 

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